Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis.
Heart tissues from hibernating mammals, such as ground squirrels, are able to endure hypothermia, hypoxia and other extreme insulting factors that are fatal for human and nonhibernating mammals.This study was designed to understand adaptive Wooden Train Set mechanisms involved in intracellular Ca(2+) homeostasis in cardiomyocytes from the mammalian