Apc-related models of intestinal neoplasia: a brief review for pathologists

Apc-related models of intestinal neoplasia: a brief review for pathologists

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Abstract Rodent models of intestinal cancer are widely used as preclinical models for human colorectal carcinoma and have proven useful in many experimental contexts, including elucidation of basic pathways of carcinogenesis and in chemoprevention studies.One of the earliest genetically engineered mouse models of intestinal cancer is the Apc Min/+ mouse, which has been Adapters used for over 25 years.This model carriers a mutation in the Apc gene, which is responsible for the inherited colon cancer syndrome, familial adenomatous polyposis coli, in humans.In this review, we discuss the pathologic features of Apc Min/+ -type intestinal adenomas and carcinomas, and compare them to the analogous human lesions.

Pitfalls of assessment of histopathology of the mouse such as non-invasive home mucosal herniation in prolapse are also described.